Butabarbital will reduce the extent or effect of zaleplon by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Importance Not known. butabarbital will decrease the extent or impact of glecaprevir/pibrentasvir by impacting hepatic/intestinal enzyme CYP3A4 metabolism. butabarbital will lower the extent or impact of prednisolone by influencing hepatic/intestinal enzyme CYP3A... https://bobbyh210hta7.shivawiki.com/user